Journal of Medicinal Chemistry p. 2548 - 2554 (1989)
Update date:2022-07-30
Topics:
Graham, Samuel L.
Shepard, Kenneth L.
Anderson, Paul S.
Baldwin, John J.
Best, Darryl B.
et al.
Derivatives of benzothiophene-2-sulfonamide were prepared to investigate their potential utility as topically active inhibitors of ocular carbonic anhydrase.Such an agent would be useful in the treatment of glaucoma.Among the compounds described are 6-hydroxybenzothiophene-2-sulfonamide (16) and its acetate ester (23), which are among the most potent ocular hypotensive agents in this class, as assessed in the α-chymotrypsinized rabbit.These compounds were selected for clinical evaluation.
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