Benzodiazepine receptor binding and anticonflict activity in a series of 3,6-disubstituted pyridazino[4,3-c]isoquinolines devoid of anticonvulsant properties

Article abstract of DOI:10.1021/jm00147a034

A series of 3,6-disubstituted pyridazino [4,3-c]isoquinolines were synthesized and tested for their ability to inhibit the binding of [³H]diazepam to rat brain receptors in vitro. Compounds bearing a phenyl, 4-methyoxyphenyl, or methyl group at