Synthesis and activity of 5-(aminomethylene)-1,3-cyclohexanediones: Enolic analogues of γ-aminobutyric acid

DOI: 10.1021/jm00148a012

Source and publish data:

Journal of Medicinal Chemistry p. 1440 - 1446 (1985)

Update date:2022-08-04

Topics:

Authors:

Mann Mann

Humblet Humblet

Chambon Chambon

Schlichter

Desarmenien

Feltz Feltz

Wermuth Wermuth

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Article abstract of DOI:10.1021/jm00148a012

Eight 1,3-cyclohexanediones with an aminoalkyl side chain in the 5-position were synthesized as rigid enolic analogues of GABA (γ-aminobutyric acid). Biochemical investigations about their abilities to displace [³H]GABA and [³H]baclo

Full text of DOI:10.1021/jm00148a012

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