Synthesis and properties of gramicidin S analogs containing Pro-D-Phe sequence in place of D-Phe-Pro sequence in the β-turn part of the antibiotic

DOI: 10.1246/bcsj.58.1469

Source and publish data:

Bulletin of the Chemical Society of Japan p. 1469 - 1472 (1985)

Update date:2022-09-26

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Authors:

Tamaki Tamaki

Takimoto

Muramatsu

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Article abstract of DOI:10.1246/bcsj.58.1469

Two analogs of gramicidin S, [L-Pro⁴, D-Phe⁵]-gramicidin S and [L-Pro(4,4'), D-Phe(5,5')]-gramicidin S, were synthesized in order to investigate the relationships among positions of Pro residues, antibiotic activity and CD spectra. [

Full text of DOI:10.1246/bcsj.58.1469

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