ASYMMETRIC ALKYLATION OF AN Α-KETO ESTER WITH CHIRAL LITHIUM ALKOXY-TRIBUTYLALUMINATES

Article abstract of DOI:10.1016/S0040-4039(00)77402-8

Lithium tetrabutylaluminate modified by either (-)-N-methylephedrine or Darvon alcohol (+)-(2S, 3R)-4-dimethylamino-3-methyl-1,2-diphenyl-2-butanol readily reacts with phenylglyoxylic acid methyl ester to give the expected α-butyl α-hydroxy ester with a good chemical yield and an optical yield of 43percent when Darvon alcohol is used.