BOTRYODIPLODIN: A MYCOTOXIN FROM PENICILLIUM ROQUEFORTI. REACTION WITH AMINO-PYRIMIDINES, AMINO-PURINES AND 2'-DEOXYNUCLEOSIDES

Article abstract of DOI:10.1016/S0040-4020(01)96415-4

Botryodiplodin is a mycotoxin isolated from a strain of Penicillium roqueforti.This toxin exhibits genotoxic properties, it inhibits cell metabolism at the level of replication, transcription and traduction; it induces DNA-protein cross-links.The chemical reaction with amino-pyrimidines and amino-purine has led to 2-aminooxolane compounds.The structure and the stereochemistry of these adducts have been studied.Likewise the reaction with various 2'-deoxynucleosides has led to similar compounds.