COMPLETELY STEREOCONTROLLED SYNTHESIS OF THE RIGHT FRAGMENT OF SALINOMYCIN, A POLYETHER ANTIBIOTIC, BY MEANS OF THE CHELATION-CONTROLLED GRIGNARD REACTION

Article abstract of DOI:10.1016/S0040-4039(00)98547-2

In the course of our synthetic study of salinomycin (1), an ionophorous polyether antibiotic, the γ-lactone (2) corresponding to the the C-21-C-30 fragment (the right fragment of 1 was synthesized from D-mannitol and ethyl L-lactate as chiral starting mat