Lithiation of 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine: synthesis of 6-substituted 2'-deoxyuridines

DOI: 10.1016/S0040-4020(01)96402-6

Source and publish data:

Tetrahedron p. 861 - 866 (1985)

Update date:2022-07-29

Topics: Synthesis Lithiation 6-substituted

Authors:

Tanaka, Hiromichi

Hayakawa, Hiroyuki

Iijima, Shuji

Haraguchi, Kazuhiro

Miyasaka, Tadashi

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Article abstract of DOI:10.1016/S0040-4020(01)96402-6

Synthesis of 6-substituted 2'-deoxyuridines can be effected by lithiation of 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine with LDA followed by the reaction of its lithio derivative with electrophiles. This method provides a general, regiosp

Full text of DOI:10.1016/S0040-4020(01)96402-6

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