Ring-substituted β-methoxyphenethylamines: A new class of psychotomimetic agents active in man

Article abstract of DOI:10.1111/j.2042-7158.1985.tb03072.x

Four members of a new class of psychotomimetic agents have been synthesized and evaluated in man. These compounds, which incorporate a β-methoxy group onto a β-phenethylamine sidechain, are the first reported psychotomimetics which are structural analogues of the neurotransmitter noradrenaline. These substances are more potent than the corresponding phenethylamines (lacking a β-methoxy group) but less potent than the correspondingly substituted amphetamine derivatives.