Inversion of Configuration at the Phosphorus Nucleophile in the Diastereoselective and Enantioselective Synthesis of P-Stereogenic syn-Phosphiranes from Chiral Epoxides

DOI: 10.1002/anie.201801427

Source and publish data:

(2018)

Update date:2022-08-04

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Authors:

Muldoon, Jake A.

Varga, Balázs R.

Deegan, Meaghan M.

Chapp, Timothy W.

E?rd?gh, ádám M.

Hughes, Russell P.

Glueck, David S.

Moore, Curtis E.

Rheingold, Arnold L.

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Article abstract of DOI:10.1002/anie.201801427

Nucleophilic substitution results in inversion of configuration at the electrophilic carbon center (S_N2) or racemization (S_N1). The stereochemistry of the nucleophile is rarely considered, but phosphines, which have a high barrier to

Full text of DOI:10.1002/anie.201801427

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