A SIMPLE CHIRAL SHIFT REAGENT FOR MEASUREMENT OF ENANTIOMERIC EXCESSES OF PHOSPHINE OXIDES

Article abstract of DOI:10.1016/S0040-4039(00)98126-7

(R)-(-)-N-(3,5-dinitrobenzoyl)-α-phenylethylamine is a chiral shift reagent which allows ee measurements of various phosphine oxides.Good results were obtained for monophosphine oxides with asymmetric phosphorus centers as well as with an asymmetric carbon in α position of phosphorus.The reagent is also able differentiate the two enantiomers of racemic DIOP dioxide.