Synthesis and Inhibition of Human Acrosin and Trypsin and Acute Toxicity of Aryl 4-Guanidinobenzoates

DOI: 10.1021/jm00154a015

Source and publish data:

Journal of Medicinal Chemistry p. 514 - 519 (1986)

Update date:2022-08-05

Topics: Synthesis Trypsin Experimental Inhibition Acute Toxicity

Authors:

Kaminski, J. M.

Bauer, L.

Mack, S. R.

Anderson, R. A.

Waller, D. P.

Zaneveld, L. J. D.

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Article abstract of DOI:10.1021/jm00154a015

The aryl 4-guanidinobenzoate, 4'-nitrophenyl 4-guanidinobenzoate (NPGB), is potent inhibitor of sperm acrosin, an enzyme with an essential function in the fertilization process.NPGB prevents fertilization in a number of animal species and is a good lead c

Full text of DOI:10.1021/jm00154a015

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