Highly efficient nitration of phenolic compounds in solid phase or solution using Bi(NO3)3·5H2O as nitrating reagent

Article abstract of DOI:10.1021/jo0514669

Bi(NO₃)₃·5H₂O was used as an efficient nitrating reagent in the nitration of phenolic compounds to give nitrated phenols in good to high yields. The nitration reaction proceeded smoothly by grinding 1 equiv of phenol, 2-methylphenol, 4-methylphenol, or 4-chlorophenol and Bi(NO₃)₃· 5H₂O, and the nitration of other phenolic compounds could be performed in acetone at ambient temperature (22-30 °C).