ASYMMETRIC SYNTHESIS OF α-AMINO β-HYDROXY PHOSPHONIC ACIDS VIA BINAP-RUTHENIUM CATALYZED HYDROGENATION

Article abstract of DOI:10.1016/00404-0399(50)11355-

BINAP-Ru catalyzed hydrogenation of configurationally labile α-amido β-keto phosphonic esters gives the (R,R)- or (S,S)-α-amido β-hydroxy phosphonic esters in a highly enantio- and diastereoselective manner.