Arylmethyl esters as protecting groups for carboxylic, carbonic and carbamic acids: Deprotection via homogeneous palladium-catalyzed hydrogenolysis

Article abstract of DOI:10.1016/S0040-4039(99)01457-4

4-Quinolylmethyl (4-QUI) esters of carboxylic acids and 1-naphthylmethyl (1-NAP) esters of carbonic and carbamic acids are reduced by palladium-catalyzed hydrogenolysis by formate anion. The reaction conditions are compatible with the presence of a benzyl ester and of an alkene double bond.