Effective transformation of aldoximes to nitriles by dehydration with 2-methylene-1,3-dioxepane in the presence of a Lewis acid catalyst

DOI: 10.1016/S0040-4039(97)01715-2

Source and publish data:

Tetrahedron Letters p. 7203 - 7206 (1997)

Update date:2022-08-30

Topics:

Authors:

Fukuzawa, Shin-Ichi

Yamaishi, Yasuhiro

Furuya, Hideki

Terao, Keiji

Iwasaki, Fumiaki

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Article abstract of DOI:10.1016/S0040-4039(97)01715-2

The dehydration of aldoximes with 2-methylene-1,3-dioxepane (MDO) proceeds smoothly in the presence of a catalytic amount of Lewis acid such as scandium(III) triflate to give corresponding nitriles in moderate to high yields under mild conditions.

Full text of DOI:10.1016/S0040-4039(97)01715-2

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