A screening procedure for the formation of nitroso derivatives and mutagens by drug-nitrite interaction

DOI: 10.1248/cpb.30.3399

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3399 - 3404 (1982)

Update date:2022-08-18

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Authors:

Takeda Takeda

Kanaya Kanaya

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Article abstract of DOI:10.1248/cpb.30.3399

A general procedure for screening for the formation of nitroso derivatives and/or mutagens by drug-nitrite interaction was established. A test drug (50 mM) was reacted with nitrite (500 mM) at pH 3.0-3.5 and 37°C for 4 h. The residual nitrite in the reaction mixture was decomposed with ammonium sulfamate. The nitrite-free reaction mixture was assayed for both nitroso derivatives and mutagens by colorimetry of Griess reagent-positive substances formed by treatment with hydrogen bromide and by mutagenesis assay using Salmonella typhimurium TA98 and TA100 as tester strains, respectively.

Full text of DOI:10.1248/cpb.30.3399

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