Enantioselective trimethylsilylcyanation of aldehydes

DOI: 10.1016/0040-4039(95)00123-T

Source and publish data:

Tetrahedron Letters p. 1625 - 1628 (1995)

Update date:2022-08-11

Topics:

Authors:

Bolm, Carsten

Mueller, Peter

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Article abstract of DOI:10.1016/0040-4039(95)00123-T

A chiral titanium reagent derived from optically active sulfoximine (R)-3 and Ti(O-i-Pr)₄ promotes the asymmetric addition of trimethylsilylcyanide to aldehydes affording cyanohydrins in high yields with good enantioselectivities (up to 91% ee).

Full text of DOI:10.1016/0040-4039(95)00123-T

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