Ligands for brain cholinergic channel receptors: Synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine

DOI: 10.1021/jm00052a005

Source and publish data:

Journal of Medicinal Chemistry p. 4455 - 4463 (1994)

Update date:2022-08-28

Topics:

Authors:

Garvey Garvey

Wasicak Wasicak

Elliott Elliott

Lebold Lebold

Hettinger

Carrera Carrera

Lin Lin

Holladay

Anderson

Cadman Cadman

Raszkiewicz

Sullivan

Arneric Arneric

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Article abstract of DOI:10.1021/jm00052a005

Ligands which activate neuronal nicotinic acetylcholine receptors (nAChRs) represent a potential approach for the palliative treatment for the symptoms of memory loss associated with Alzheimer's disease (AD). Based upon this approach, a series of novel 3,

Full text of DOI:10.1021/jm00052a005

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