Synthesis and in vitro evaluation of 18F- and 19F-labeled insulin: A new radiotracer for PET-based molecular imaging studies

DOI: 10.1021/jm0509344

Source and publish data:

Journal of Medicinal Chemistry p. 1466 - 1474 (2006)

Update date:2022-08-16

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Authors:

Guenther, Katharina J.

Yoganathan, Sabesan

Garofalo, Robert

Kawabata, Thomas

Strack, Thomas

Labiris, Renée

Dolovich, Myrna

Chirakal, Raman

Valliant, John F.

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Article abstract of DOI:10.1021/jm0509344

A new and regioselective strategy was developed for the preparation of fluorine-18-labeled insulin as a novel positron emission tomography (PET) tracer. [¹⁸F]-4-Fluorobenzoic acid (4-¹⁸FBA), which was produced in 83 ± 8% yield (n = 1

Full text of DOI:10.1021/jm0509344

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