Optically active aminoalcohol promoted addition of 2-pyridylthioester boron enolates to imines: Enantioselective one-pot synthesis of β-lactams

Article abstract of DOI:10.1016/0040-4020(95)00503-Z

The enolates derived from 2-pyridylthioesters by treatment with BCl₃·Me₂S and enantiomerically pure aminoalcohols react with aromatic and heteroaromatic imines to afford β-lactams in a convenient one-pot procedure and in up to 78% e.