Synthesis, anorexigenic activity and QSAR of substituted aryloxypropanolamines

Article abstract of DOI:10.1007/s00044-004-0107-6

Substituted aryloxypropanolamines (6-20) were synthesized and evaluated for their anorexigenic activity. Among them 4-cyanoaryloxy (7), 2-methylaryloxy (9), 2-methoxyl aryloxy (10), 4-acetamidoaryloxy (15), 4-bromoaryloxy (16) and 4-ethylaminoaryloxy (20) exhibited potent anorexigenic activity. According to QSAR studies, the electronic parameter 'σ' plays an important role in describing the variance in activity. Birkhaeuser Boston 2004.

Full text of DOI:10.1007/s00044-004-0107-6

Med Chem Res 13:8/9 (2004) 631–642
௠ Birkha¨user Boston 2004

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