Purines. LIX. An alternative synthesis of 7-alkyl-1-methyladenines by regioselective alkylation, fission, and reclosure of the adenine ring

DOI: 10.1248/cpb.42.151

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 151 - 153 (1994)

Update date:2022-08-11

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Authors:

Fujii Fujii

Saito Saito

Suzuki Suzuki

Kunugi Kunugi

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Article abstract of DOI:10.1248/cpb.42.151

7-Alkyl-1-methyladenines (12a,b) have been synthesized from 1-alkyl-4- aminoimidazole-5-carboxamides (5a,b) in two steps [hence from adenine (1) in six steps]. The synthesis started with dehydration (using POCl₃-HCONMe₂) of 5a,b, rea

Full text of DOI:10.1248/cpb.42.151

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