
Tetrahedron Letters p. 3607 - 3608 (1996)
Update date:2022-08-16
Topics:
Harrowven, David C.
Dainty, Richard F.
6-Methoxytetralins may be smoothly transformed into 5-methoxytetralins through the action of zirconium tetrachloride. The rearrangement occurs at ambient temperature in chloroform and proceeds via fragmentation of the carbon-carbon bond para to the methoxy substituent followed by an intramolecular Friedel-Crafts alkylation.
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