Two-carbon chain extension of chiral aldehydes via 2-alkenylthiazoles: Synthesis of γ-functionalized alkanals

Article abstract of DOI:10.1055/s-1993-25844

The reaction of 2-thiazolylmethylenetriphenylphosphorane (1a) in benzene with various aldehydes gives 2-alkenylthiazoles in variable E/Z ratios. Application of the thiazole-to-formyl deblocking protocol to the mixture of the olefins leads to saturated ald