One-Pot Synthesis of Unsymmetrical Ketones by the Reaction of Decacarbonyldimanganese with Two Kinds of Alkyllithiums

Article abstract of DOI:10.1246/bcsj.69.157

Decacarbonyldimanganese (Mn₂(CO)₁₀) is utilized as a phosgene equivalent for the one-pot preparation of unsymmetrical ketones. By a successive treatment of Mn₂(CO)₁₀ with two kinds of alkyllithiums, unsymmetrical ketones are obtained in high selectivity. Unsymmetrical α-diketones are generated when the above reaction is carried out in the presence of trimethyl phosphite and is quenched with N-bromosuccinimide.