Michael-type reactions of tenulin, a biologically active sesquiterpene lactone

Article abstract of DOI:10.1002/jps.2600721228

The antitumor pseudoguainolide tenulin has been exposed to a wide variety of biological and model nucleophilic reagents and has been shown to react exclusively with sulfur nucleophiles in a Michael-like fashion. The biological implications of these results are discussed.