Journal of the Chemical Society. Perkin transactions I p. 385 - 388 (1987)
Update date:2022-08-25
Topics:
Mann, John
Pietrzak, Barbara
A new route to 19,19-difluoroandrost-4-ene-3,17-dione (2) has been devised, in which the key step is the reaction of (diethylamino)sulphur trifluoride (DAST) with 3,19-dioxandrost-4-en-17β-yl benzoate (5).A novel rearrangement product (7) was also produced in this reaction.Compound (2) and its 4-hydroxy derivative (3; R=H) inhibited human placental aromatase in vitro, but were not as potent as 4-hydroxyandrost-4-ene-3,17-dione (1).
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