An efficient preparation of novel epoxyketone intermediates for the synthesis of carfilzomib and its derivatives

Article abstract of DOI:10.3184/174751916X14539789662063

A novel and efficient preparation of epoxyketone intermediates for the synthesis of carfilzomib and its derivatives has been developed. Compared to reported methods, this highly stereoselective, environmentally friendly, low-cost method can be used in scaling up the synthesis of carfilzomib and its derivatives.