An Unusual Chemoselectivity in Cobalt(II) Chloride Catalysed Cleavage of Oxiranes with Anilines: A Highly Regioselective Synthesis of β-Amino Alcohols

Article abstract of DOI:10.1016/0040-4039(90)87039-3

Cobalt(II) chloride catalyses the regioselective cleavage of oxiranes with anilines and p-methoxyaniline to the corresponding β-amino alcohols in excellent yields.Benzylic and aliphatic amines do not react under these conditions.