Tetrahedron Letters p. 1777 - 1780 (1985)
Update date:2022-08-04
Topics:
Carpenter, Andrew J.
Chadwick, Derek J
The course of lithiation of furan- and thiophene-2-carboxylic acids is critically dependent on the identity of the lithium base allowing high-yielding syntheses of 2,3- and 2,5-disubstituted thiophenenes: the proposed use of a trimethylsilyl blocking group to control metallation in the furan acid provides a useful route to 2,3-disubstituted furans.
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