Synthesis of 2-amino-5-aryl-1,3,4-thiadiazoles and their condensed analogs with the use of aromatic nitriles

Article abstract of DOI:10.1007/BF00707235

Aromatic nitriles are found to readily react with thiosemicarzide and 4-amino-3-methyl-1,2,4-triazol-5-thione in a solution of polyphosphoric acid to give corresponding 2-amino-5-aryl-1,3,4-thiadiazoles. - Keywords: aromatic nitriles, polyphosphoric acid,