Synthesis of DNA Containing Modified Bases by Postsynthetic Substitution. Synthesis of Oligomers Containing 4-Substituted Thymine: O4-Alkylthymine, 5-Methylcytosine, N4-(Dimethylamino)-5-methylcytosine, and 4-Thiothymine

DOI: 10.1021/jo00040a024

Source and publish data:

Journal of Organic Chemistry p. 3839 - 3845 (1992)

Update date:2022-08-11

Topics:

Authors:

Xu, Yao-Zhong

Zheng, Qinguo

Swann, Peter F.

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Article abstract of DOI:10.1021/jo00040a024

A strategy is described for synthesis of oligomers modified in the 4-position of thymine by postsynthetic substitution. 4-Triazolothymine phosphoramidite monomer has been prepared in one step from thymine amidite monomer and incorporated into a 12 mer AGC

Full text of DOI:10.1021/jo00040a024

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