ASYMMETRIC HYDROGENATION OF α-ACYLAMINOACRYLIC ACIDS AND ESTERS WITH AXIALLY DISSYMMETRIC BISAMINOPHOSPHINE-RHODIUM COMPLEXES

Article abstract of DOI:10.1246/cl.1980.729

From easily resolved 2,2'-diamino-1,1'-binaphthyl were prepared axially dissymmetric bisphosphine ligands, (R)- and (S)-2,2'-bis(diphenylphosphinamino)-1,1'-binaphthyl; the rhodium-catalyzed asymmetric hydrogenation of α-acylaminoacrylic acids and esters gave the corresponding amino acids of up to 95percent optical purity.