Photoredox catalysts: Synthesis of the bipyrazine ligand

Article abstract of DOI:10.1021/jo502925u

The bipyrazine ligand is often employed in photoredox catalysts in order to increase the excited state oxidation potential of the catalyst. However, literature syntheses of the ligand are cumbersome and typically lead to low yields. This hampers use of the desired catalysts. We report here an efficient copper based synthesis of the bipyrazine ligand that affords the product in 65-76% yield on a multigram scale.

Full text of DOI:10.1021/jo502925u

Subscriber access provided by NJIT | New Jersey Institute of Technology
Note
Photoredox Catalysts: Synthesis of the Bipyrazine Ligand
Matthew D. Graaf, and Kevin D. Moeller
J. Org. Chem., Just Accepted Manuscript • DOI: 10.1021/jo502925u • Publication Date (Web): 08 Jan 2015
Downloaded from http://pubs.acs.org on January 13, 2015
Just Accepted
“Just Accepted” manuscripts have been peer-reviewed and accepted for publication. They are posted
online prior to technical editing, formatting for publication and author proofing. The American Chemical
Society provides “Just Accepted” as a free service to the research community to expedite the
dissemination of scientific material as soon as possible after acceptance. “Just Accepted” manuscripts
appear in full in PDF format accompanied by an HTML abstract. “Just Accepted” manuscripts have been
fully peer reviewed, but should not be considered the official version of record. They are accessible to all
readers and citable by the Digital Object Identifier (DOI®). “Just Accepted” is an optional service offered
to authors. Therefore, the “Just Accepted” Web site may not include all articles that will be published
in the journal. After a manuscript is technically edited and formatted, it will be removed from the “Just
Accepted” Web site and published as an ASAP article. Note that technical editing may introduce minor
changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers
and ethical guidelines that apply to the journal pertain. ACS cannot be held responsible for errors
or consequences arising from the use of information contained in these “Just Accepted” manuscripts.
The Journal of Organic Chemistry is published by the American Chemical Society.
1155 Sixteenth Street N.W., Washington, DC 20036
Published by American Chemical Society. Copyright © American Chemical Society.
However, no copyright claim is made to original U.S. Government works, or works
produced by employees of any Commonwealth realm Crown government in the course
of their duties.

Page 1 of 10
The Journal of Organic Chemistry
1
2
3
4
5
6
7
8
9
Photoredox Catalysts: Synthesis of the Bipyrazine Ligand
Matthew D. Graaf and Kevin D. Moeller*
Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
*
Email: moeller@wustl.edu
Received Date (will be automatically inserted after manuscript is accepted)
Abstract:
The bipyrazine ligand is often employed in photoredox catalysts in order to increase the excited state
oxidation potential of the catalyst. However, literature syntheses of the ligand are cumbersome and
typically lead to low yields. This hampers use of the desired catalysts. We report here an efficient
copper based synthesis of the bipyrazine ligand that affords the product in 65-76% yield on a multigram
scale.
_
_________________________________________________________________________
Photoredox catalysts offer a convenient and unique method for the generation and use of both
1
radical cation and radical anion intermediates in synthesis. Because of our long standing interest in the
2
,3
radical cation intermediates that play a critical role in net oxidative cyclization reactions, we were
curious as to the chemical reactivity of the radical cations generated with the use of a photoredox
catalyst and how that reactivity compared to that of radical cations generated at the surface of an
4
,5
anode. We hoped to examine the reactivity of the radical cations using the same competition study
6
methods employed for the analysis of the electrochemical reactions (Scheme 1). Would the use of the
photoredox conditions and the presence of the radical anion in the reaction alter the chemoselectivity of
the radical cation reactions?
The substrates typically used for the electrochemical experiments (Scheme 1) have oxidation
6
potentials that range from about +0.9 V vs. Ag/AgCl to +1.4 V vs. Ag/AgCl. For this reason, the
ruthenium derived photoredox catalyst using a bipyrazine ligand was selected for the photochemical
ACS Paragon Plus Environment

The Journal of Organic Chemistry
Page 2 of 10
7
8
oxidation. This catalyst has an excited state with an oxidation potential of around +1.4 V. For
1
2
3
4
5
6
7
8
9
1
1
1
1
1
1
1
1
1
1
2
2
2
2
2
2
2
2
2
2
3
3
3
3
3
3
3
3
3
3
4
4
4
4
4
4
4
4
4
4
5
5
5
5
5
5
5
5
5
5
6
8
comparison, the bipyridine ruthenium catalyst has an excited state oxidation potential of +0.77 V.
Scheme 1
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
While the selection of an appropriate catalyst was straight forward, the overall plan ran into trouble
when it came time to make the desired catalyst. The ligand proved difficult to synthesize on a scale that
would allow for its use in multiple transformations. Many of the papers that describe the use of the
9
bipyrazine ligand, cite the work of Lafferty and Case for its synthesis. This synthesis begins with the
pyrazine carboxylic acid (Scheme 2), and utilizes a Cu-based aryl – aryl coupling reaction to generate
the ligand. The reaction requires elevated temperatures and produces the ligand in a 7% yield.
Scheme 2
Yoon and coworkers published an improved synthesis of the bipyrazine ligand that took advantage of a
1
0
Pd-catalyzed coupling reaction to afford a 42% yield of the product (Scheme 3).
ACS Paragon Plus Environment

Page 3 of 10
The Journal of Organic Chemistry
Scheme 3
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
For our part, we sought an improved, scalable synthesis of the bipyrazine ligand that still took
advantage of an Earth abundant metal catalyst. Of particular note was the Cu-based strategy developed
1
1
by Lipshutz and coworkers for the formation of mixed biaryl systems. In this chemistry (Scheme 4), a
mixed copper catalyst system is generated from an aryl lithium that was typically formed by metal
halogen exchange with the corresponding aryl halide. Unfortunately, this method did not prove
amenable to the synthesis of the bipyrazine ligand from the pyrazine halide.
Scheme 4
Methods for generation of the aryllithium, the nature of the oxidant used, and the time and
temperature of the reaction were all vaired. The maximum yield obtained from these optimization
efforts was only 35%. The amount of the initial pyrazine halide recovered from the reaction and the
subsequent results discussed below indicated that the reaction was limited by formation of the necessary
aryllithium species.
With that conclusion, we sought an alternative method to make the necessary cuprate. One method
1
2
of interest modified the Lipshutz approach with a direct ortho cupration. In this work, Wheatley,
Uchiyama, and coworkers made use of an amino-base cuprate to deprotonate the aryl group and
generate the arylcuprate without any need to generate the aryllithium species. They demonstrated that
the resulting arylcuprates can either be trapped with electrophiles or treated with oxidants to provide the
biaryl homocoupling product. When the same conditions were attempted with pyrazine, the reaction led
ACS Paragon Plus Environment

The Journal of Organic Chemistry
Page 4 of 10
to a 20% yield of the homocoupling product along with 20% of the recovered starting material. It
appeared that the oxidative step of the process was hindering the reaction.
1
2
3
4
5
6
7
8
9
1
1
1
1
1
1
1
1
1
1
2
2
2
2
2
2
2
2
2
2
3
3
3
3
3
3
3
3
3
3
4
4
4
4
4
4
4
4
4
4
5
5
5
5
5
5
5
5
5
5
6
Nguyen and coworkers demonstrated that a similar approach could be used for the formation of
13
biaryls from heterocycles. For this chemistry, the nature of the cuprate was modified and a stronger
oxidant used. These conditions turned out to be the best starting point for our optimization of a route to
the bipyrazine ligand (Table 1). Initially (entry 1), conditions identical to those employed by Mongin
and coworkers were used. The reaction led to a 41% yield of the bipyrazine product. Nguyen and
coworkers also utilized p-dinitrobenzene as an oxidant for the reaction. The use of this oxidant led to a
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
3
9% of the bipyrazine (entry 2). As a control, only 10% of the product was generated in the absence of
acid (entry 3).
Table 1. Optimization of Bipyrazine Formation
Entry
1
2
Oxidant
Chorinal
Dinitro-
Conditions
60 C, 16 h
RT, 16 h
Variation
Yield
41%
39%
o
--
--
benzene
3
4
5
6
--
RT, 16 h
60 C, 16 h
--
--
--
10%
45%
--
o
Duroquinone
Duroquinone
Duroquinone
Reflux, 16 h
o
60 C, 16 h
0.5 equiv
TMEDA
--
39%
7
8
9
Duroquinone
Duroquinone
--
Sonicated,
56%
76%
18%
54%
58%
25%
45%
43%
50%
25%
1
0 min
Sonicated,
60 min
Sonicated,
--
--
6
0 min
Sonciated,
0 min
1
1
1
0
1
2
Duroquinone
0.5 equiv
oxidant
--
6
Methyl-
anthraquinone
Cloranil
Sonicated,
60 min
Sonicated,
60 min
--
--
13
Benzoquinone
Duroquinone
Duroquinone
Duroquinone
Sonicated,
6
0 min
Sonicated,
0 min
Sonicated,
0 min
Sonicated,
0 min
1
1
1
4
5
6
1.25 equiv
LiCu(TMP)2
0.5 equiv.
LiCu(TMP)2
Li Cu(TMP)2
6
6
2
6
CN
ACS Paragon Plus Environment

Page 5 of 10
The Journal of Organic Chemistry
Iyoda and coworkers showed that duroquinone could serve as a successful oxidant for the
1
2
1
4
generation of biaryl systems from arylcopper species. When this observation was combined with the
Nguyen approach and applied to the formation and oxidation of pyrazinyl cuprate, the reaction led to a
3
4
5
6
7
8
9
1
1
1
1
1
1
1
1
1
1
2
2
2
2
2
2
2
2
2
2
3
3
3
3
3
3
3
3
3
3
4
4
4
4
4
4
4
4
4
4
5
5
5
5
5
5
5
5
5
5
6
4
5% yield of product (entry 4).
In each of the cases tried, the addition of pyrazine to the reaction led to the formation of a solid
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
suspended in the THF. The result was a poor yield of the desired product combined with low recovery
20-25%) of the starting material. This observation was most consistent with the poor solubility of the
(
cuprate hindering the oxidation step in the sequence.
One method to circumvent such issues by improving the solubility of the cuprate is to heat the
reaction. In the case of bipyrazine generation this led to decomposition of the starting material and no
evidence product formation (entry 5). A second method was suggested by Lipschutz and coworkers. For
their reactions, they report that the addition of TMEDA to the reactions before the oxidation step
1
5
afforded higher yields of the biaryl product. The authors hypothesized that the addition of the TMEDA
led to chelation of lithium ions in solution, a change that activated the cuprate complex for oxidation.
We hoped that the addition might help solublize the copper complex. However, the addition led to no
improvement in the reaction (entry 6).
In a third attempt to solubilize the cuprate, the reaction was sonicated for 10 min following addition
of the duroquinone oxidant to the mixture. The yield of the reaction improved to 56% (entry 7). When
the duration of the sonication/oxidation step was increased to 60 min, the yield of bipyrazine product
climbed further to 76% (entry 8). From the reaction mixture, a 23% yield of recovered pyrazine was
obtained. In addition, 90% of the original mass of the duroquinone oxidant was recovered. When the
oxidant was removed from the reaction (entry 9), the yield dropped to only 18%. When 0.5 equivalents
of the oxidant was used (entry 10), the reaction proceeded to just over 50% completion. Hence, the was
required for reductive elimination of the aryl rings from the cuprate intermediate. Sonication alone was
not enough.
ACS Paragon Plus Environment

The Journal of Organic Chemistry
Page 6 of 10
With the optimized conditions for the reaction established, a several different oxidants with varying
oxidation potential were screened for their ability to trigger the reductive elimination reaction (entries
11-13). However, the none of the three were as effective as duroquinone for the reaction.
1
2
3
4
5
6
7
8
9
1
1
1
1
1
1
1
1
1
1
2
2
2
2
2
2
2
2
2
2
3
3
3
3
3
3
3
3
3
3
4
4
4
4
4
4
4
4
4
4
5
5
5
5
5
5
5
5
5
5
6
The nature of the cuprate intermediate was also examined using the optimized reaction conditions
(entries 14-16). Once again, the original cuprate derived from direct deprotonation of pyrazine proved to
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
be the best.
Finally, the scalability of the reaction was examined (Scheme 5). To this end, the reaction wasrun on a
multigram scale leading to 2.05grams (ca. 65%) of the bipyrazine ligand.
Scheme 5
In conclusion, a rapid, convenient synthesis of the bipyrazine ligand needed for higher oxidation
potential Ru-based photoredox catalysts has been developed. The availability of this method should
greatly improve the availability of the catalyst.
Experimental Section:
General Information:
Tetrahydrofuran (THF) was dried by distilling over sodium and benzophenone. 2,2,6,6,-
Tetramethylpiperidine (TMP) was dried over molecular sieves prior to use. All remaining reagents were
purchased commercially and used without further purification.
Preperation of CuCl ⋅TMEDA Complex:
2
16
Synthesis was taken and modified from previous literature procedure . In a flame dried 1000 mL
round bottom flask, 23.86 g (140 mmol) Copper(II) Chloride dihydrate was suspended in 700 mL
butanol and refluxed. 21 mL (140 mmol) N,N,N’,N’-tetramethylethylenediamine (TMEDA) was
ACS Paragon Plus Environment

Page 7 of 10
The Journal of Organic Chemistry
dissolved in 50 mL butanol and added slowly to the refluxing copper solution. Refluxing continued for
5 minutes before cooling to room temperature. The resulting copper complex was precipitated with
1
2
3
4
5
6
7
8
9
1
1
1
1
1
1
1
1
1
1
2
2
2
2
2
2
2
2
2
2
3
3
3
3
3
3
3
3
3
3
4
4
4
4
4
4
4
4
4
4
5
5
5
5
5
5
5
5
5
5
6
1
hexane, filtered and dried under vacuum. 74% yield (25.9 g) of CuCl ⋅TMEDA was obtained.
2
Cuprate mediated synthesis of Bipyrazine:
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
In a flame dried 25 mL round bottom flask, 500mg CuCl ⋅TMEDA (2.0 mmol) was suspended in 5
2
mL THF and cooled to 0°C. The copper(II) suspension was reduced with the dropwise addition of 1.25
mL (2.0 mmol) n-Butyllithium solution (1.6M in hexanes) resulting in a light green Cu(I) solution.
(Note: Butyllithium solution must be free of lithium salts. Also, it should be added slowly under
sufficient stirring to avoid overreduction of copper).
In a separate, flame dried 10 mL round bottom, 0.63 mL (4.0 mmol) TMP was dissolved in 2 mL
THF and cooled to 0°C. 1eq. n-Butyllithium was added before warming to room temperature.
The LiTMP was then added slowly to the Cu(I) mixture at 0°C yielding a dark yellow solution
containing the necessary LiCu(TMP) complex. 160 mg (2.0 mmol) pyrazine was dissolved in 1 mL
2
THF before dropwise addition to the copper solution. Upon completion, the mixture was allowed to
warm to room temperature and stir for 2 hours resulting in the formation of a dark brown precipitate.
The cuprate suspension was oxidized with 394 mg (1.2 eq.) duroquinone while sonicated for 1 hour.
The resulting mixture was quenched with water and extracted with dichloromethane. All organic layers
were combined, dried over magnesium sulfate, filtered and solvent removed under reduced pressure.
Crude product was purified by column chromatography using 1:1 Ethyl Acetate in Hexanes. 120 mg
bipyrazine (76% yield, MW = 158.16 g/mol) was obtained with no further purification needed.
1
7 1
Bipyrazine (5). H NMR (300MHz, CDCl ) δ = 9.61ppm (s, 2H); 8.67 (s, 4H)
3
Large Scale Synthesis of Bipyrazine:
In a flame dried 1000 mL Morton flask (to maintain sufficient agitation of reaction mixture), 10.0g
CuCl ⋅TMEDA (40.0 mmol) was suspended in 100 mL THF and cooled to 0°C. 25 mL (40.0 mmol) n-
2
Butyllithium solution (1.6M in hexanes) was added dropwise yielding Cu(I) solution.
ACS Paragon Plus Environment

The Journal of Organic Chemistry
Page 8 of 10
1
2
3
4
5
6
7
8
9
1
1
1
1
1
1
1
1
1
1
2
2
2
2
2
2
2
2
2
2
3
3
3
3
3
3
3
3
3
3
4
4
4
4
4
4
4
4
4
4
5
5
5
5
5
5
5
5
5
5
6
In a separate, flame dried 100 mL round bottom, 13.6 mL (80.0 mmol) TMP was dissolved in 40 mL
THF and cooled to 0°C. 1eq. n-Butyllithium was added before warming to room temperature.
The LiTMP was then added slowly to the Cu(I) mixture at 0°C yielding a dark yellow solution
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
containing the necessary LiCu(TMP) complex. 3.2 g (40.0 mmol) pyrazine was dissolved in 1mL THF
2
before dropwise addition to the copper solution. Upon completion, the mixture was allowed to warm to
room temperature and stir for 2 hours. Oxidation occurred with the addition of 7.88 g (1.2 eq.)
duroquinone and sonicated for 1.5 hours. The resulting mixture was quenched with water and extracted
with dichloromethane. All organic layers were combined, dried, filtered and solvent removed in-vacuo.
Crude product was purified by column chromatography using 1:1 Ethyl Acetate in Hexanes yielding
2
.05 g bipyrazine (65%).
Associated Content:
Supporting Information
.
1
H spectrum of bipyrazine product (Table 1, Entry 8). This material is available free of charge via the
Internet at http://pubs.acs.org.
Author Information
Corresponding Author:
*
Email: moeller@wustl.edu
Notes:
Authors declare no competing financial interest.
Acknowledgment.
We thank the National Science Foundation (CHE-1151121) for their generous support of this work.
References:
1
. For a review see Schultz, D. M.; Yoon, T. P. Science 2014, 343.
ACS Paragon Plus Environment

Page 9 of 10
The Journal of Organic Chemistry
2
3
. For a review see Moeller, K. D. Synlett. 2009, 8, 1208.
1
2
3
4
5
6
7
8
9
1
1
1
1
1
1
1
1
1
1
2
2
2
2
2
2
2
2
2
2
3
3
3
3
3
3
3
3
3
3
4
4
4
4
4
4
4
4
4
4
5
5
5
5
5
5
5
5
5
5
6
. For recent examples see: (a) Smith, J. A.; Moeller, K. D. Org. Lett. 2013, 15, 5818. (b) Redden, A.;
Perkins, R. J.; Moeller, K. D. Angew. Chem. Int. Ed. 2013, 52, 12865.
4
. For applications of radical cations in synthesis see: (a) Okada, T.; Akaba, R.; Chiba, K. Org. Lett.
2
009, 11, 1033. (b) Floreancig, P. E. Synlett 2007, 2, 0191-0203. (c) Jung, H. H.; Seiders II, J. R.;
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
Floreancig, P. E. Angew. Chem. Int. Ed. 2007, 46, 8464. (d) Green, M. E.; Rech, J. C.; Floreancig, P.
E. Angew. Chem. Int. Ed. 2008, 47, 7317. (e) Tu, W.; Liu, L.; Floreancig, P. E. Angew. Chem. Int.
Ed. 2008, 47, 4184. (f) Liu, L.; Floreancig, P. E. Angew. Chem. Int. Ed. 2010, 49, 5894. (g) Liu, L.;
Floreancig, P. E. Org. Lett. 2009, 11, 3152. (h) Devery III, J. J.; Conrad, J. C.; MacMillan, D. W. C.;
Flowers II, R. A. Angew. Chem. Int. Ed. Eng. 2010, 49, 6106 and references therein. (i) Beeson, T.
D.; Mastracchio, A.; Hong, J. –B.; Ashton, K.; MacMillan, D. W. C. Science 2007, 316, 582. (j) Jang,
H. –Y.; Hong, J. –B.; MacMillan D. W. C. J. Am. Chem. Soc. 2007, 129, 7004. (k) Baran, P. S.;
Ambhaikar, N. B.; Guerroro, C. A.; Hafensteiner, B. D.; Lin, D. W.; Richter, J. M. ARKIVOC 2006,
310. (l) Clift, M. D.; Taylor, C. N.; Thomson, R. J. Org. Lett. 2007, 9, 4667. (m) Ischay, M. A.; Lu,
Z.; Yoon, T. P. J. Am. Chem. Soc. 2010, 132, 8572. (n) Okada, Y.; Nishimoto, A.; Akaba, R.; Chiba,
K. J. Org. Chem. 2011, 76, 3470. (o) Nguyen, T. M.; Monohar, N.; Nicewicz, D. A. Angew. Chem.
Int. Ed. 2014, 53, 6198. (p) Nicewicz, D. A.; Nguyen T. M. ACS Catalysis 2014, 4, 355.
5
. For radical cation initiated cyclizations derived from chemical and photoelectron-transfer based
oxidations see: (a) Crich, D.; Ranganathan, K.; Neelamkavil, S.; Huang, X. J. Am. Chem. Soc. 2003,
1
25, 7942. (b) Crich, D.; Shirai, V.; Brebion, F.; Rumthao, S. Tetrahedron 2006, 62, 6501. (c) Crich,
D.; Ranganathan, K. J. Am. Chem. Soc. 2005, 127, 9924. (d) Crich, D.; Shirai, M.; Rumthao, S. Org.
Lett. 2003, 5, 3767. (e) Conrad, J. C.; Kong, J.; Laforteza, B. N.; MacMillan, D. W. C. J. Am. Chem.
Soc. 2009, 131, 11640. (f) Jui, N. T.; Lee, E. C. Y.; MacMillan, D. W. C. J. Am. Chem. Soc. 2010,
1
32, 10015. (g) Rendler, S.; MacMillan, D. W. C. J. Am. Chem. Soc. 2010, 132, 5027. (h) Nguyen, T.
M.; Nicewicz, D. A. J. Am. Chem. Soc. 2013, 135, 10334.
6
. Campbell, J. M.; Xu, H. -C.; Moeller, K. D. J. Am. Chem. Soc. 2012, 134, 18388.
ACS Paragon Plus Environment

The Journal of Organic Chemistry
. Crutchley, R. J.; Lever, A. B. P. J. Am. Chem. Soc. 1980, 102, 7129.
. Yoon, T. P. ACS Catalysis 2013, 3, 895.
Page 10 of 10
7
8
1
2
3
4
5
6
7
8
9
1
1
1
1
1
1
1
1
1
1
2
2
2
2
2
2
2
2
2
2
3
3
3
3
3
3
3
3
3
3
4
4
4
4
4
4
4
4
4
4
5
5
5
5
5
5
5
5
5
5
6
9. Lafferty, J. J.; Case, F. H. J. Org. Chem. 1967, 32, 1591.
1
0. (a) Lin, S.; Ischay, M. A.; Fry, C. G.; Yoon, T. P. J. Am. Chem. Soc. 2011, 133, 19350, Supporting
Information. (b) For a similar Pd method: Boully, L.; Darabantu, M.; Turck, A.; Plé, N. J.
Heterocyclic Chem. 2005, 42, 1423.
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
1
1. Lipshutz, B. H.; Siegmann, K.; Garcia, E. J. Am. Chem. Soc. 1991, 113, 8161.
12. Usui, S.; Hashimoto, Y.; Morey, J. V.; Wheatley, A. E. H.; Uchiyama, M. J. Am. Chem. Soc. 2007,
29, 15102.
3. Nguyen, T. T.; Marquise, N.; Chevallier, F.; Mongin, F. Chem. Eur. J. 2011, 17, 10405.
1
1
14. (a) Miyake, Y.; Wu, M.; Rahman, M. J.; Iyoda, M. Chem. Commun. 2005, 411. (b) Miyake, Y.; Wu,
M.; Rahman, M. J.; Kuwatani, Y.; Iyoda, M. J. Org. Chem. 2006, 71, 6110.
1
5. Lipshutz, B.; Seigmann, K.; Garcia, E.; Kayser, F. J. Am. Chem. Soc. 1993, 115, 9277.
16. Bertini, I. and Mani, F. Inorganic Chemistry. 1967, 6, 2032
7. Fort, Y.; Becker, S.; and Caube`re, P. Tetrahedron, 1994, 50, 11893
1
Graphical Abstract:
ACS Paragon Plus Environment