Direct reductive amination of aldehydes and ketones with 2,4-ionene-based borohydride exchange resin as a novel polymer-supported reducing agent

Article abstract of DOI:10.1080/00397910801997769

Direct reductive amination of aldehydes and ketones were accomplished efficiently using high-capacity, ionene-based, polymer-supported borohydride reagent in isopropyl alcohol at reflux under neutral conditions. The reagent is easily prepared by mixing aqueous solution of 2,4-ionene bromide with an alkaline solution of sodium borohydride at room temperature. The generality of reaction was established using both aliphatic and aromatic aldehydes, ketones, and amines. Copyright Taylor & Francis Group, LLC.