Chemical and Pharmaceutical Bulletin p. 1676 - 1678 (1994)
Update date:2022-08-11
Topics:
Sumita
Koumori
Ohno
Mannich reaction of ketones using 1,3-dioxolane instead of formaldehyde, paraformaldehyde, or 1,3,5-trioxane afforded the corresponding Mannich bases in high yields. Under the same conditions the aminomethylation of aromatics did not proceed but the intramolecular aminomethylation, like a Pictet-Spengler type reaction, proceeded smoothly.
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