Synthesis p. 846 - 849 (1985)
Update date:2022-08-11
Topics:
Barluenga, Jose
Florez, Josefa
Yus, Miguel
The preparation of γ-functionalised secondary organoalkaline metal compounds starting from methyl 3-chlorobutanoate (obtained by addition of hydrogen chloride to commercially available methyl trans-2-butenoate) is described.Reactions of these metallated compounds with suitable electrophilic reagents leads to a variety of tertiary alcohol derivatives.
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