ALKYLATION DE QUELQUES COMPOSES CARBONYLES PAR DES GROUPES TERTIAIRES. UTILISATION DE LA REACTION DE FRIEDEL-CRAFTS DANS LA SYNTHESE D'ESTERS ET DE CETONES ENCOMBRES

Article abstract of DOI:10.1016/S0040-4020(01)92017-4

t-Alkylation of carboxylic esters via their ketene alkyl trimethylsilyl acetels by the Friedel-Crafts reaction allows the synthesis of new higly hindered compounds.A new route using sodium amide in dimethoxyethane, for the preparation of trimethylsilyl enol ethers of ketones, is described.The α-butylation of these compounds permits the synthesis of new crowded pentasubstituted ketones.The limits as well as the performance of the method have been studied.