
Tetrahedron Letters p. 1639 - 1642 (1993)
Update date:2022-08-11
Topics:
Tsunoda, Tetsuto
Yamamiya, Yoshiko
Ito, Sho
The 1,1′-(azodicarbonyl)dipiperidine (ADDP)-tributylphosphine (TBP) system was developed as a new institute of the Mitsunobu reagent. The new system activates nitrogen or carbon nucleophiles, known to be innert or poorly reactive with the Mitsunobu reagent, to react with alcohols satisfactorily forming C-N or C-C bonds. The inversion of stereogenic carbinyl carbons was confirmed in the acylaltion reaction of two sec-alcohols.
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