A facile one-pot preparation of isothiocyanates from aldoximes

Article abstract of DOI:10.1016/S0040-4039(97)00121-4

Isothiocyanates 2a-l were prepared in excellent yields in a one-pot reaction from aldoxime derivatives 1a-l by successive treatment of aldoxime with N-chlorosuccinimide (NCS), thiourea, and triethylamine. The use of HCl/DMF/Oxone system in the reaction instead of NCS was equally effective.