An improved and practical sharpless oxidation of primary alcohols to the carboxylic acids

Article abstract of DOI:10.1080/00397919908086465

An improved and practical procedure for the oxidation of primary alcohols to the carboxylic acids under Sharpless's conditions (NaIO₄/RuCl₃.H₂O/water/acetonitrile) using ethyl acetate as the solvent, in place of toxic and ecologically undesirable carbon tetrachloride, is described.

Full text of DOI:10.1080/00397919908086465

This article was downloaded by: [University of Waterloo]
On: 10 November 2014, At: 08:09
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic Organic
Chemistry
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lsyc20
An Improved and Practical Sharpless
Oxidation of Primary Alcohols to the
Carboxylic Acids
a
a
a
a
Mahavir Prashad , Yansong Lu , Hong-Yong Kim , Bin Hu
a
a
,
a
Oljan Repic & Thomas J. Blacklock
Process Research & Development, Chemical & Analytical
Development Novartis Institute for Biomedical Research , 59
Route 10, East Hanover, New Jersey, 07936, USA
Published online: 25 Sep 2007.
To cite this article: Mahavir Prashad , Yansong Lu , Hong-Yong Kim , Bin Hu , Oljan
Repic & Thomas J. Blacklock (1999) An Improved and Practical Sharpless Oxidation of
Primary Alcohols to the Carboxylic Acids, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 29:17, 2937-2942, DOI:
10.1080/00397919908086465
To link to this article: http://dx.doi.org/10.1080/00397919908086465
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information
(
&
the “Content”) contained in the publications on our platform. However, Taylor
Francis, our agents, and our licensors make no representations or warranties
whatsoever as to the accuracy, completeness, or suitability for any purpose of the
Content. Any opinions and views expressed in this publication are the opinions and
views of the authors, and are not the views of or endorsed by Taylor & Francis. The
accuracy of the Content should not be relied upon and should be independently
verified with primary sources of information. Taylor and Francis shall not be liable

for any losses, actions, claims, proceedings, demands, costs, expenses, damages,
and other liabilities whatsoever or howsoever caused arising directly or indirectly in
connection with, in relation to or arising out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden.
Terms & Conditions of access and use can be found at http://www.tandfonline.com/
page/terms-and-conditions