Reaction of alkyl sulfoxides and phenylphosphinic acid with amines. Alternative reagents for secondary amines N-alkylation

Article abstract of DOI:10.1080/00397919108016414

Phenylphosphinic acid and dialkylsulfoxides are found to be alternative reagents for respectively the reducing reagent (formic acid) and the alkylating reagent (aldehyde) currently used for secondary amines N-alkylation. Primary amines do not react with this system, but phenylglycine is decarboxilated to benzylamine.

Full text of DOI:10.1080/00397919108016414

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Synthetic Communications: An
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Reaction of Alkyl Sulfoxides
and Phenylphosphinic Acid
with Amines. Alternative
Reagents for Secondary Amines
N-Alkylation
R. Chauvin a
a Laboratoire de Synthèse Asymétrique , Université
Paris-Sud , 91 405, Orsay, France
Published online: 24 Sep 2006.
To cite this article: R. Chauvin (1991) Reaction of Alkyl Sulfoxides and
Phenylphosphinic Acid with Amines. Alternative Reagents for Secondary
Amines N-Alkylation, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 21:14, 1425-1428, DOI:
10.1080/00397919108016414
To link to this article: http://dx.doi.org/10.1080/00397919108016414
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