The ortho-substituted N,N-diacetylaniline as a selective acetylating reagent

Article abstract of DOI:10.1016/S0040-4039(97)00745-4

Selective acetylation of the less hindered amino group in the presence of the more hindered amino group with the use of 2-trifluoromethyl-N,N-diacetylaniline 2c is described. This acetylation with 2c yielded the corresponding less hindered monoacetamide exclusively, simply, conveniently, and in good yields.