Advanced Synthesis and Catalysis p. 3325 - 3330 (2014)
Update date:2022-08-11
Topics:
Buslov, Ivan
Hu, Xile
We describe a new method for the intermolecular amination of the α-C-H bonds of ethers. A hypervalent iodine reagent was used as oxidant to enable the amination of cyclic and acyclic alkyl ethers with a wide range of amides, imides, and amines. The amination occurred at room temperature and without a transition metal catalyst. The method could be used to synthesize the anti-cancer prodrug Tegafur and its analogues.
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