Samarium Diiodide Mediated Alkylation of Saturated Heterocycles alpha to Nitrogen

DOI: 10.1016/0040-4020(95)00081-I

Source and publish data:

Tetrahedron p. 3665 - 3674 (1995)

Update date:2022-08-17

Topics:

Authors:

Booth, Susan E.

Benneche, Tore

Undheim, Kjell

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Article abstract of DOI:10.1016/0040-4020(95)00081-I

A method for α-alkylation of saturated 5-, 6-, 7- and 8-membered aza-heterocycles is described.The auxiliary is an o-iodobenzyl group attached at the nitrogen.A radical introduced in the o-position is transferred to the amine α-position which subsequently leads to an addition reaction with pentan-3-one.

Full text of DOI:10.1016/0040-4020(95)00081-I

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