Investigations on N,N-Dialkylbenzamides by NMR Spectroscopy. 5 - Analysis of Static and Dynamic Proton NMR Spectra of 2-Fluoro- and 2,6-Difluoro-N,N-dimethyl- and N,N-Diethyl-benzamides

Article abstract of DOI:10.1002/omr.1270211103

The analysis of static and dynamic proton NMR spectra of 2-fluoro- and 2,6-difluoro-N,N-dimethyl- and N,N-diethyl-benzamides at various temperatures has been carried out.The conformations of the compounds have been deduced on the basis of long-range through-space proton-fluorine couplings.Free energies of activation of amide rotation have been determined for all compounds, and of carbonyl-ring rotation for one compound.