The synthesis and evaluation of functionalized estratropones: Potent inhibitors of tubulin polymerization

DOI: 10.1016/S0960-894X(97)00327-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1851 - 1856 (1997)

Update date:2022-08-12

Topics:

Authors:

Miller, Thomas A.

Bulman, Amanda L.

Thompson, Charles D.

Garst, Michael E.

Macdonald, Timothy L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00327-2

The synthesis of several ex-substituted estratropones is described. The compounds were evaluated for the inhibition of tubulin polymerization using purified bovine brain tubulin. Several of the compounds are equipotent to colchicine for their ability to inhibit the polymerization of tubulin.

Full text of DOI:10.1016/S0960-894X(97)00327-2

Products guided by the article

Product name:17-BETA-ESTRADIOL 3-METHYL ETHER

Cas No:1035-77-4

R&D Labs maybe for 1035-77-4

Nanjing Fayekong Chemcial Co.,Ltd(expird)

Contact:86-25-58813444

Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
Shanghai Hanshare Industry Co.,Ltd.

Contact:86 21 20960688

Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
Shenzhen Sunrising Industry Co., ltd.

Contact:+86 755 86571158 / 86571159 / 86571160

Address:2108 ZHENYE INT. BUSINESS CENTER,NO.3101-90 QIANHAI RD, NANSHAN,SHENZHEN, CHINA
Xi'an Unique Electronic and Chemical Co., Ltd.

Contact:+86-029-88238008

Address:1703# B BUILDING WEST ELECTRONIC ZONE, XI'AN, CHINA
ShangHai BMG Chemical Co., Ltd

Contact:+86-13524845543

Address:Room 602, no 291 sikai road shanghai

Relevant to this article

Discovery of 3,6-disubstutited-imidazo[1,2-a]pyridine derivatives as a new class of CLK1 inhibitors

Doi:10.1016/j.bmcl.2021.127881
(2021)
Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4

Doi:10.1016/j.bmc.2006.01.046
(2006)
RADICAL REDUCTION OF C-Cl BONDS IN CHLOROFLUORO ETHERS

Doi:10.1135/cccc19930565
(1993)
Doi:10.1246/bcsj.12.226
(1937)
A Selective Monodehydration of C_4-14-α,ω-Alkanediols with Stearic and/or Palmitic Acids

Doi:10.1246/bcsj.54.1585
(1981)
Indium(III)-catalyzed reductive bromination and iodination of carboxylic acids to alkyl bromides and iodides: Scope, mechanism, and one-pot transformation to alkyl halides and amine derivatives

Doi:10.1021/jo401529j
(2013)

Article Doi