Bioorganic and Medicinal Chemistry Letters p. 1851 - 1856 (1997)
Update date:2022-08-12
Topics:
Miller, Thomas A.
Bulman, Amanda L.
Thompson, Charles D.
Garst, Michael E.
Macdonald, Timothy L.
The synthesis of several ex-substituted estratropones is described. The compounds were evaluated for the inhibition of tubulin polymerization using purified bovine brain tubulin. Several of the compounds are equipotent to colchicine for their ability to inhibit the polymerization of tubulin.
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