The synthesis and evaluation of functionalized estratropones: Potent inhibitors of tubulin polymerization

DOI: 10.1016/S0960-894X(97)00327-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1851 - 1856 (1997)

Update date:2022-08-12

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Authors:

Miller, Thomas A.

Bulman, Amanda L.

Thompson, Charles D.

Garst, Michael E.

Macdonald, Timothy L.

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Article abstract of DOI:10.1016/S0960-894X(97)00327-2

The synthesis of several ex-substituted estratropones is described. The compounds were evaluated for the inhibition of tubulin polymerization using purified bovine brain tubulin. Several of the compounds are equipotent to colchicine for their ability to inhibit the polymerization of tubulin.

Full text of DOI:10.1016/S0960-894X(97)00327-2

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