European Journal of Medicinal Chemistry p. 365 - 381 (1996)
Update date:2022-08-16
Topics:
Saito
Furumoto
Ochiai
Hosono
Hoshino
Haraguchi
Ikeda
Shimada
Sodium sulfates 11-14, 29-32, 35 and 37 of various alkyl glycyrrhizin and related compounds were synthesized. In vitro anti-HIV activities of the sulfates were compared to the activities of glycyrrhizin 1 in the inhibition of replications of HTLV-III and GUN-4. The activities of the sulfates were increased 11.1, 15.2, 9.1 and 5.0 times for 11-14, 100.0, 125.5, 83.3 and 11.6 times for 29-32, and 11.6 and 50.0 times for 35 and 37. From the relationship between CMC values and anti-HIV activities of the sulfates, it appeared that the sulfates exhibiting more potent antiviral activities had higher micelle forming abilities. Sodium sulfates having a triterpenoid or steroid ring in-the molecule showed more potent activities than those of thioglycosides which had no such ring. From the investigation of syncytium formation, we suggest that the active sulfates inhibited HIV-1 infection early in the replication cycle of the virus.
View MoreContact:86 311 85902108 / 85902109
Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
website:http://www.cheminn.com/
Contact:86-531-67875205
Address:No.9-2,South of Shanda Road, Jinan ,China
Lianyungang Ningkang Chemical Co., Ltd
Contact:.+86-518-88588008
Address:http://www.chemnk.com
Shanghai Hanshare Industry Co.,Ltd.
Contact:86 21 20960688
Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
Contact:86-310-8067016
Address:East Fuhua Road,Tiexi Chemical Industrial Estate,Hebei,China
Doi:10.1002/hlca.19500330706
(1950)Doi:10.1016/j.dyepig.2018.07.019
(2018)Doi:10.1039/c9ob00357f
(2019)Doi:10.1039/c6cc06372a
(2016)Doi:10.1039/b009053k
(2001)Doi:10.1016/j.ultsonch.2012.07.016
(2013)