Nickel-Catalyzed Synthesis of Arylacetonitriles from Arylzinc Chlorides and Bromoacetonitrile

DOI: 10.1055/s-1987-27834

Source and publish data:

Synthesis p. 40 - 42 (1987)

Update date:2022-08-17

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Authors:

Frejd, Torbjoern

Klingstedt, Tomas

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Article abstract of DOI:10.1055/s-1987-27834

Arylacetonitriles are synthesised by coupling arylzinc chlorides with bromoacetonitrile using Ni(acac)2/P(c-C6H11)(C6H5)2 as catalyst.The arylacetonitriles are reduced in situ with LiAlH4/AlCl3 to give the corresponding 2-aryl-1-aminoethanes.

Full text of DOI:10.1055/s-1987-27834

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